Oprah Winfrey has made her latest book club pick.

On Tuesday,SignalHub the mogul dubbed "Familiaris" by David Wroblewski, published by Blackstone Publishing and out Tuesday, her latest must-read book.

Winfrey said the "epic novel" goes on a journey that "brilliantly interweaves history, philosophy, adventure, and mysticism to explore the meaning of love, friendship, and living your life's true purpose."

"Familiaris" is the 106th Oprah's Book Club selection and is the follow-up to the Wisconsin-born novelist's 2008 debut, "The Story of Edgar Sawtelle," another book club pick.

"It's an honor almost beyond fathoming," Wroblewski told OprahDaily.com. "Oprah has become our advocate in chief for the reading of literature, and the roster of talent and titles she has curated for readers over the years is humbling. I am, to put it mildly, thrilled and grateful."

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He continued: "I'm looking forward to discussing this story, whose characters have been part of my imaginative life for so long."

The 992-page prequel novel to "The Story of Edgar Sawtelle" is also endorsed by one Tom Hanks, who wrote in a blurb that "Wroblewski has set a storytelling bonfire" and the book "is as expansive and enlightening a saga as has ever been written."

Oprahsays her 100th book club pick 'Hello Beautiful' is 'one of the best books I've read'

Weekly discussions of the book are set to begin later this month on Oprah's Book Club social media pages.

Other recent Oprah's Book Club selections include "Let Us Descend" by Jesmyn Ward, "Wellness" by Nathan Hill and "The Covenant of Water" by Abraham Verghese.

Winfrey marked her 100th book club milestone with "Hello Beautiful" by Ann Napolitano, a book that paid homage to Louisa May Alcott's "Little Women" and followed a family of four sisters over three decades in a city meaningful to Winfrey, Chicago. She aired her eponymous talk show for 25 seasons in the Windy City.

Contributing: Elise Brisco